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KMID : 0360220130540010143
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Journal of the Korean Ophthalmological Society
2013 Volume.54 No. 1 p.143 ~ p.148
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Decorin and TGF-β Expression after Partial Myotomy of the Extraocular Muscle in Rat
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Lim Young-Jin
Kim Gyu-Nam
Lee Na-Eun
Kim Seong-Jae
Yoo Ji-Myong
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Abstract
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Purpose: To report the expression of decorin and TGF-β in partial myotomy of the extraocular muscle in rats.
Methods: Partial myotomy of the superior rectus muscle was performed on the right eye of 10 Sprague-Dawley rats followed by exposure of the left superior rectus muscle and a simple suture of the conjunctiva. The bilateral superior rectus muscle was obtained from all rats at 2 weeks postoperatively. The tissues were observed under light microscopy with hematoxylin- eosin, Masson’s trichrome staining and immunohistochemistry.
Results: Histological examinations of the surgical area at 2 weeks after postoperatively showed irregularly concentrated fibrosis on light microscopy with hematoxylin-eosin and Masson’s trichrome staining of the experimental eyes. Immnohistochemistry showed that expression of decorin was in the same location as TGF-β in the experimental group.
Conclusions: The expression of decorin was found in the healing process after partial myotomy of the extraocular muscle in rats. Immunohistochemistry showed that expression of decorin was in the same location as with TGF-β.
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KEYWORD
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Decorin, Extraocular muscle, Fibrosis, Tumor growth factor
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